Healthcare Professionals

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Doctors know a patient's age; weight; height; sex; other medications; liver and kidney function: when they prescribe. However, what they don't know is how the patient will metabolise the drug.

Pharmacogenomics covers the relationship between variations in a person's genes and drug metabolising enzymes that determine a patient's response to medications. Genetic testing can define metabolism status and can help doctors prescribe the right dose level and determine if a particular drug is suitable. This testing can reduce the risk of side effects and sometimes tell if the drug will work in a particular patient or not.

GenesFX Health provides a detailed drug specific pharmacogenomic test report called DNAdose, to help determine drug dose and interpret whether a drug is suitable for a particular person. This will assist in decisions about which medication to prescribe and the dose.

DNAdose may be of benefit when prescribing the following medications:

  • Antidepressants
  • Warfarin
  • Clopidogrel
  • Analgesics such as Codeine and Tramadol
  • Tamoxifen
  • Proton pump inhibitors
  • Antihypertensives

Other drug categories which benefit from a DNAdose can be accessed by members using the Search by Category function

Why test for more multiple genes at once?

Many drugs are metabolised by more than one enzyme and many people are on more than one drug at any one time or during their lifetime.
DNAdose tests from common variants for the following genes simultaneously: CYP2D6, CYP2C19, CYP2C9, VKORC1.

Which Patients?

Whilst there are different opinions whether testing is required for all patients, testing is recommended by many doctors for

  • Those patients that experience adverse drug reactions to specific medications 
  • Non-responders to specific medication
  • Those drugs where the therapeutic action does not commence for some weeks and there is trial and error involved e.g. antidepressants.
  • Hospitalised patients
  • Patients receiving mulitple medications 
  • Those patients who have a complex mixture of multiple drugs, symptoms and possible adverse events where a greater understanding of the components is sought.
  • Children taking drugs usually prescribed for adults.
  • Potentially all patients prescribed medication


Benefits

By ordering a DNAdose for your patients, you will gain access to the GenesFX Health online service, enabling you to:

  • Minimise the "trial and error" approach to prescribing
  • Find drug management alternatives when altered metabolism is found
  • Find drugs that best match your patients genetic make-up
  • Quickly identify drugs that should be avoided by your patient
  • Identify drugs where genetic tests are shown to be informative
  • Identify potential drug-gene interactions before prescribing
  • Where known, identify CYP450 drug-drug interactions

Features

The GenesFX Health website provides healthcare professional with access to the following benefits:

  • A "Personalised Drug Specific Report" with in depth clinical analysis
  • Offers a multiple gene test (DNAdose) involving more than 40% of common medications including testing for 5 out of 10 of the most commonly used medications and many others.
  • Testing by the only NATA accredited pharmacogenomics laboratory in Australia with rapid turnaround time.