Medications

Overview

GenesFX Health provides gene testing for approximately 50% of currently prescribed medications. A person's genetic makeup plays an important role in how the body processes the medication. 

Genetic testing  can define metabolism status and can help doctors prescribe the right dose and determine if a particular drug is suitable .This area of medicine is known as pharmacogenomics. Pharmacogenomic testing can reduce the risk of side effects and sometimes tell if the drug will work in a particular patient or not. This provides a more presonalised approach to drug prescribing.

The test is evidence based and provides doctors with another tool that they can use in clinical decision-making by;

• Finding the right drug and the right dose
• Safer use of medications by minimising Adverse Drug Reactions
• Improving therapeutic response to prescribed medications
• Quality use of medicines

Substrates

Below is a list of drugs (substrates) that are metabolised by specific CYP450 enzymes.  

Inhibitors

Inhibitors bind to the enzyme and reduce the enzyme activity in metabolising the substrate (drug). A strong inhibitor greatly decreases the amount of drug metabolised. This may lead to an increase in side effects for active drugs and a decrease in effect for pro-drugs. Weak inhibitors have a minimal effect on this process; therefore they are not included in the list below.

Strong and moderate inhibitors are listed below according to the specific enzyme they inhibit:  

Inducers

Inducers stimulate the production of an enzyme which increases the rate of metabolism of a drug.  Examples of enzyme inducers are listed below:

This information is not intended to be a substitute for medical advice.